Cimzia package insert pdf

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Supartz, a solution of sodium hyaluronate, is one of the hyaluronates used in viscosupplementation. The sodium hyaluronate used in Supartz is extracted from chicken combs.

Sodium hyaluronate is a polysaccharide which contains repeating disaccharide units of glucuronic acid and N-acetylglucosamine. FDA on January 24, 2001 for the treatment of knee osteoarthritis in patients who failed to obtain sufficient relief with conservative treatments, including exercise, physical therapy, pain medications, mobility aids, and hot or cold packs. Use for other joints is being investigated.

Supartz was used in Japan since 1987. It is injected once a week for a 5-week cycle. Some patients may have a good response after 3 weeks. 10 mg sodium hyaluronate dissolved in 1.

Supartz, allowing for repeat injection cycles. While the safety label was expanded for repeat cycles of injection, the effectiveness of repeat cycles has not been established. Caution should be used when treating patients with known allergy to avian proteins, eggs, or feathers. Patients with an infection or skin disease in the area where the injection would be given should not be treated with Supartz.

The safety and effectiveness of Supartz has not been established in pregnant women, nor in lactating women. Its use has not been studied in children.

Patients are advised to avoid strenuous or weightbearing activities in the 48 hours following injection. While the safety of Supartz and the other viscosupplements has been upheld by clinical studies, effectiveness has been debated. Regarding effectiveness, a Cochrane Review concluded that viscosupplementation is more effective than placebo, but there were other studies that fell short on proving that the injections provide significant pain relief.